Telescope opens

Structure that Opens the Gate and Opens the Door

Sometimes the best way to solve a problem is to look at it from a different perspective. That is certainly the case in ion channel research. Hodgkin and Huxley must have realized that 50 years ago when they looked at membrane currents with a voltage clamp, and Sakmann and Neher realized it 20 years ago when they measured Possible Symmetries of Tetrameric Channel single-channel currents with the...

Testing for tunneling opens

A tunneling-open failure mode is proposed and carefully studied. A circuit with a tunneling open could pass at-speed Boolean tests but fail VLV testing or IDDQ testing. Theoretical calculations as well as Boolean and IDDQ experiments confirm the existence of tunneling opens. The Murphy experimental data show that seven out of nine VLV-only failure circuits can be explained by this failure mode....

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Invadolysin opens many doors

Making a raft with oligomers pithelial cells differentially segregate proteins to their apical and basolateral surfaces. For some apical localization events, association of glycosylphosphatidylinositol (GPI)anchored proteins with detergent-resistant rafts is necessary but not sufficient. Now, on page 699, Paladino et al. show that the key for proper protein sorting may be the formation of high ...

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